High Salt Elicits Brain Inflammation and Cognitive Dysfunction, Accompanied by Alternations in the Gut Microbiota and Decreased SCFA Production
Journal of Alzheimer s Disease2020Vol. 77(2), pp. 629–640
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Li Hu, Shaoping Zhu, Xiaoping Peng, Kanglan Li, Wanjuan Peng, Yu Zhong, Chenyao Kang, Xingxing Cao, Zhou Liu, Bin Zhao
Abstract
The HSD directly causes cognitive dysfunction in mice by eliciting an inflammatory environment and triggering apoptosis in the brain, and these effects are accompanied by gut dysbiosis, particularly reduced SCFA production.
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