Olfactory Impairment Is Related to Tau Pathology and Neuroinflammation in Alzheimer’s Disease
Journal of Alzheimer s Disease2021Vol. 80(3), pp. 1051–1065
Citations Over TimeTop 10% of 2021 papers
Julia Klein, Xinyu Yan, Aubrey S. Johnson, Zeljko Tomljanovic, James Zou, Krista Polly, Lawrence S. Honig, Adam M. Brickman, Yaakov Stern, Davangere P. Devanand, Seonjoo Lee, William Charles Kreisl
Abstract
Olfactory identification deficits are related to extent of tau pathology and neuroinflammation, particularly in those with amyloid pathophysiology. The independent association of amyloid-positivity and cognitive impairment with odor identification suggests that low UPSIT performance may be a marker for AD pathophysiology in cognitive normal individuals, although impaired odor identification is associated with both AD and non-AD related neurodegeneration.NCT Registration Numbers: NCT03373604; NCT02831283.
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