The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation
Health Technology Assessment2009Vol. 13(52), pp. 1–148
Citations Over TimeTop 1% of 2009 papers
Corri Black, Christine Clar, Robyn J. Henderson, Campbell F. MacEachern, Paul McNamee, Zahidul Quayyum, P Royle, Siân Thomas
Abstract
There was evidence that glucosamine sulphate shows some clinical effectiveness in the treatment of OA of the knee. No trial data came from the UK and caution should be exercised in generalising the findings to the UK health-care setting. Cost-effectiveness was not conclusively demonstrated. There was evidence to support the potential clinical impact of glucosamine sulphate. The value of information analysis identified three research priorities: QoL, structural outcomes and knee arthroplasty. The biological mechanism of glucosamine sulphate and chondroitin remains uncertain and, in particular, the proposal that the active substance may be sulphate should be explored further.
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