Clinical effectiveness and cost-effectiveness of stem cell transplantation in the management of acute leukaemia: a systematic review
Health Technology Assessment2010Vol. 14(54), pp. iii–iv, ix
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Khalid Ashfaq, Ismail Yahaya, Christopher Hyde, Lazaros Andronis, P Barton, Susan Bayliss, Yen‐Fu Chen
Abstract
Bearing in mind the limitations, existing evidence suggests that sibling donor allogeneic SCT may be more effective than chemotherapy in adult AML (except in good-risk patients) in CR1, childhood AML in CR1 and adult ALL in CR1, and that autologous SCT is equal to or less effective than chemotherapy. No firm conclusions could be drawn regarding the cost-effectiveness of SCT in the UK NHS owing to the limitations given above. Future research should include the impact of the treatments on patients' quality of life as well as information on health service use and costs associated with SCT from the perspective of the UK NHS.
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