Genetic isolation of quantitative trait loci for blood pressure development and renal mass on chromosome 5 in the spontaneously hypertensive rat
Citations Over TimeTop 10% of 2003 papers
Abstract
Total genome scans of genetically segregating populations derived from spontaneously hypertensive rats (SHR) and other rat models of essential hypertension suggested a presence of quantitative trait loci (QTL) regulating blood pressure on multiple chromosomes, including chromosome 5. The objective of the current study was to test directly a hypothesis that chromosome 5 of the SHR carries a blood pressure regulatory QTL. A new congenic strain was derived by replacing a segment of chromosome 5 in the SHR/Ola between the D5Wox20 and D5Rat63 markers with the corresponding chromosome segment from the normotensive Brown Norway (BN/Crl) rat. Arterial pressures were directly monitored in conscious, unrestrained rats by radiotelemetry. The transfer of a segment of chromosome 5 from the BN strain onto the SHR genetic background was associated with a significant decrease of systolic blood pressure, that was accompanied by amelioration of renal hypertrophy. The heart rates were not significantly different in the SHR compared to SHR chromosome 5 congenic strain. The findings of the current study demonstrate that gene(s) with major effects on blood pressure and renal mass exist in the differential segment of chromosome 5 trapped within the new SHR.BN congenic strain.
Related Papers
- → Dissecting quantitative trait loci into opposite blood pressure effects on Dahl rat chromosome 8 by congenic strains(2004)39 cited
- → Two Linked Blood Pressure Quantitative Trait Loci on Chromosome 10 Defined by Dahl Rat Congenic Strains(2001)35 cited
- → Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat(2017)14 cited
- → Chromosome 2 Reciprocal Congenic Strains to Evaluate the Effect of the Genetic Background on Blood Pressure(2002)6 cited
- → Faculty Opinions recommendation of Two linked blood pressure quantitative trait loci on chromosome 10 defined by dahl rat congenic strains.(2001)