Dynamic Changes of Orexin A and Leptin in Obese Children during Body Weight Reduction

Citations Over TimeTop 23% of 2007 papers

Abstract

In this study, we describe changes of plasma levels of the hypothalamic neuropeptide orexin A in obese children during the reduction of body weight and its relationship to other biochemical and anthropometrical parameters. We measured orexin A fasting plasma levels by the RIA method in 58 obese children--33 girls and 25 boys; mean age 13.1+/-0.38 years (range 7-18.5) before and after 5 weeks of weight-reduction therapy. Leptin, IGF-1, and IGFBP-3 levels were measured in all the subjects and were compared to orexin A levels and anthropometrical data. Average weight in subjects before weight-reduction was 74.2+/-2.79 kg and after weight-loss 67.4+/-2.60 kg (p<0.0001). Orexin A levels before the therapy were 33.3+/-1.97 pg/ml and after the therapy 51.7+/-3.07 pg/ml (p<0.0001). Levels of orexin A were not significantly different between girls and boys (p=0.7842). We found negative correlation between orexin A and age (r = -0.5395; p<0.0001), body height (r = -0.4751; p=0.0002), body weight (r = -0.4030; p=0.0017) and BMI (r = -0.2607; p=0.0481). No correlation was found between orexin A and IGF-1, IGFBP-3 or leptin. Orexin A plasma levels increased during body weight loss, whereas the reverse was true for leptin levels. These findings support the hypothesis that orexin A may be involved in regulation of nutritional status in children.

Related Papers

• → Orexin-induced food intake involves neuropeptide Y pathway(2000)260 cited
• → Stimulation of feeding behavior and food consumption in the goldfish, Carassius auratus, by orexin-A and orexin-B(1999)150 cited
• → Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity(2001)105 cited
• → Orexin-A and Orexin-B During the Postnatal Development of the Rat Brain(2009)36 cited
• → Orexin A及[Ala11, D-Leu15] orexin-B在大鼠環導水管灰質切片作用之電生理研究(2007)