Recent Progress in the Genetics of Spontaneously Hypertensive Rats
Citations Over TimeTop 10% of 2014 papers
Abstract
The spontaneously hypertensive rat (SHR) is the most widely used animal model of essential hypertension and accompanying metabolic disturbances. Recent advances in sequencing of genomes of BN-Lx and SHR progenitors of the BXH/HXB recombinant inbred (RI) strains as well as accumulation of multiple data sets of intermediary phenotypes in the RI strains, including mRNA and microRNA abundance, quantitative metabolomics, proteomics, methylomics or histone modifications, will make it possible to systematically search for genetic variants involved in regulation of gene expression and in the etiology of complex pathophysiological traits. New advances in manipulation of the rat genome, including efficient transgenesis and gene targeting, will enable in vivo functional analyses of selected candidate genes to identify QTL at the molecular level or to provide insight into mechanisms whereby targeted genes affect pathophysiological traits in the SHR.
Related Papers
- → Investigation of Obesity Candidate Genes On Porcine Fat Deposition Quantitative Trait Loci Regions(2004)73 cited
- → Efficient metaphase II transgenesis with different transgene archetypes(2001)65 cited
- → Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms(2008)13 cited
- → Mammalian and Avian Transgenesis — New Approaches(2006)17 cited
- → Mapping of candidate genes associated with late blight resistancein potato and comparison of their location with known quantitative trait loci(2008)3 cited