The Role and Mechanism of CRT0066101 as an Effective Drug for Treatment of Triple-Negative Breast Cancer
Cellular Physiology and Biochemistry2019Vol. 52(3), pp. 382–396
Citations Over TimeTop 10% of 2019 papers
Yan Liu, Yuzhi Wang, Shiyi Yu, Yehui Zhou, Xinxing Ma, Qian Su, An Li, Feifei Wang, Aihua Shi, Jingzhong Zhang, Liming Chen
Abstract
PRKD inhibitor CRT0066101 exhibits anti-TNBC effects via modulating a phosphor-signaling network and inhibiting the phosphorylation of many cancer-driving factors, including MYC, MAPK1/3, AKT, YAP, and CDC2, providing insight into the important roles as well as the molecular mechanism of CRT0066101 as an effective drug for TNBC.
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