A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems
Frontiers in Physiology2016Vol. 7, pp. 469–469
Citations Over TimeTop 10% of 2016 papers
Jiaxi Xu, Snigdha Mukerjee, Cristiane R. A. Silva-Alves, Alynne Carvalho‐Galvão, Josiane C. Cruz, Camille M. Balarini, Valdir A. Braga, Eric Lazartigues, Maria S. França-Silva
Abstract
ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences several physiological and pathological processes. This review focuses on the structure of ADAM17, its signaling in the cardiovascular system and its participation in certain disorders involving the heart, blood vessels, and neural regulation of autonomic and cardiovascular modulation.
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