The Interplay between Dysregulated Metabolism and Epigenetics in Cancer
Citations Over TimeTop 16% of 2023 papers
Abstract
Cellular metabolism (or energetics) and epigenetics are tightly coupled cellular processes. It is arguable that of all the described cancer hallmarks, dysregulated cellular energetics and epigenetics are the most tightly coregulated. Cellular metabolic states regulate and drive epigenetic changes while also being capable of influencing, if not driving, epigenetic reprogramming. Conversely, epigenetic changes can drive altered and compensatory metabolic states. Cancer cells meticulously modify and control each of these two linked cellular processes in order to maintain their tumorigenic potential and capacity. This review aims to explore the interplay between these two processes and discuss how each affects the other, driving and enhancing tumorigenic states in certain contexts.
Related Papers
- → Epigenetic mechanisms in Alzheimer's disease: Implications for pathogenesis and therapy(2013)133 cited
- → Transgenerational Epigenetic Contributions to Stress Responses: Fact or Fiction?(2016)90 cited
- → Epigenetic reprogramming during tissue regeneration(2011)59 cited
- → Epigenetic Landmarks During Somatic Reprogramming(2016)4 cited
- → Advanced Technologies Lead iNto New Reprogramming Routes(2016)