The Nutriepigenome

Citations Over Time

Abstract

Unlike genetic changes, epigenetics modulates gene expression without stable modification of the genome. Even though all cells, including sperm and egg, have an epigenome pattern, most of these modifications occur during lifetime and interestingly, some of them, are reversible. Lifestyle and especially nutrients as well as diet regimens are presently gaining importance due to their ability to affect the epigenome. On the other hand, since the epigenome profoundly affects gene expression profile it can be speculated that the epigenome could modulate individual response to nutrients. Recent years have thus seen growing interest on nutrients, macronutrients ratio and diet regimens capable to affect the epigenetic pattern. In fact, while genetic alterations are mostly detrimental at the individual level, reshaping the epigenome may be a feasible strategy to positively counteract the detrimental effect of aging. Here, I review nutrient consumption and diet regimens as a possible strategy to counteract aging-driven epigenome derangement.

Related Papers

• → Maternal care, the epigenome and phenotypic differences in behavior(2007)265 cited
• → Nutrition and the Epigenome(2012)33 cited
• → Nutrition, epigenetics and health through life(2017)14 cited
• → Cause and effect in epigenetics – where lies the truth, and how can experiments reveal it?(2020)4 cited
• → The Ability of Nutrition to Mitigate Epigenetic Drift: A Novel Look at Regulating Gene Expression(2021)1 cited