Updated Insight into the Physiological and Pathological Roles of the Retromer Complex
International Journal of Molecular Sciences2017Vol. 18(8), pp. 1601–1601
Citations Over TimeTop 11% of 2017 papers
Abstract
Retromer complexes mediate protein trafficking from the endosomes to the trans-Golgi network (TGN) or through direct recycling to the plasma membrane. In yeast, they consist of a conserved trimer of the cargo selective complex (CSC), Vps26-Vps35-Vps29 and a dimer of sorting nexins (SNXs), Vps5-Vps17. In mammals, the CSC interacts with different kinds of SNX proteins in addition to the mammalian homologues of Vps5 and Vps17, which further diversifies retromer functions. The retromer complex plays important roles in many cellular processes including restriction of invading pathogens. In this review, we summarize some recent developments in our understanding of the physiological and pathological functions of the retromer complex.
Related Papers
- → Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1(2010)147 cited
- → Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs(2016)65 cited
- → WDR91 specifies the endosomal retrieval subdomain for retromer-dependent recycling(2022)20 cited
- → Retromer Sets a Trap for Endosomal Cargo Sorting(2016)7 cited
- → The Role of Retromer in Neurodegenerative Disease(2009)4 cited