Experimental Human Pneumococcal Carriage
Journal of Visualized Experiments2013Iss. 72
Citations Over TimeTop 10% of 2013 papers
Jenna F. Gritzfeld, Angie D. Wright, Andrea M. Collins, Shaun H. Pennington, Adam Wright, Aras Kadioglu, Daniela M. Ferreira, Stephen B. Gordon
Abstract
Our current protocol has been safe in over 100 volunteers at a range of doses using two different bacterial serotypes. A dose ranging study using S. pneumoniae 6B and 23F is currently being conducted to determine the optimal inoculation dose for 50% carriage. A predicted 50% rate of carriage will allow the EHPC model to have high sensitivity for vaccine efficacy with small study numbers.
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