Clonal resistance analyses of HIV type-1 after failure of therapy with didanosine, lamivudine and tenofovir
Antiviral Therapy2009Vol. 15(3), pp. 437–441
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Abstract
Mutants with K65R and M184V linked on the same genome were the most common HIV-1 variants in samples analysed from patients failing TNV, ddI and 3TC with both mutations detected by standard genotype. The double mutant exhibited reduced susceptibility to all three NRTIs in the regimen. This resistant phenotype, resulting from just two linked point mutations, likely contributes to rapid failure of NRTI combinations that exclude zidovudine.
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