MicroRNAs: Novel regulatory molecules in acute lung injury/acute respiratory distress syndrome
Citations Over TimeTop 13% of 2016 papers
Abstract
Acute lung injury (ALI) and the more severe acute respiratory distress syndrome (ARDS) are common and complex inflammatory lung diseases. MicroRNAs (miRNAs), a type of non-coding RNA molecule that regulate gene expression at the post-transcriptional level, have emerged as a novel class of gene regulators, which have critical roles in a wide range of human disorders and diseases, including ALI. Certain types of miRNAs are abnormally expressed in response to lung injury. miRNAs can regulate inflammation pathways by targeting specific molecules and modulate immune response in the process of lung injury and repair. The regulation of miRNA can relieve injury response and promote the recovery of ALI/ARDS. Therefore, miRNAs may serve as novel therapeutic targets in ALI/ARDS.
Related Papers
- → Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)(2010)9 cited
- → Application of therapeutic signaling gas for acute lung injury(2013)2 cited
- → 39.9 ARDS (acute respiratory distress syndrome)ARDS = acute respiratory distress syndrome [J80](2013)
- → New insights on relationship of acute respiratory distress syndrome and diffuse alveolar damage(2020)
- Consequences and Causes of Acute Respiratory Distress Syndrome[ARDS](2020)