Gold nanoparticle-enhanced Photodynamic therapy: Effects of Surface Charge and Mitochondrial Targeting
Therapeutic Delivery2015Vol. 6(3), pp. 307–321
Citations Over TimeTop 10% of 2015 papers
Abstract
Positively charged Au NPs were preferably taken up by breast cancer cells. Combination of positive surface charge with mitochondria-targeting domain onto Au NPs allowed their accumulation in the mitochondria of breast cancer cells to significantly elevate reactive oxygen species formation in 5-aminolevulinic-acid-enabled photodynamic therapy and improve selective destruction of breast cancer cells.
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