Receptor protein complexes are in control of autophagy
Autophagy2012Vol. 8(11), pp. 1701–1705
Citations Over TimeTop 10% of 2012 papers
Dalibor Mijaljica, Taras Y. Nazarko, John H. Brumell, Wei‐Pang Huang, Masaaki Komatsu, Mark Prescott, Anne Simonsen, Ai Yamamoto, Hong Zhang, Daniel J. Klionsky, Rodney J. Devenish
Abstract
In autophagic processes a variety of cargos is delivered to the degradative compartment of cells. Recent progress in autophagy research has provided support for the notion that when autophagic processes are operating in selective mode, a receptor protein complex will process the cargo. Here we present a concept of receptor protein complexes as comprising a functional tetrad of components: a ligand, a receptor, a scaffold and an Atg8 family protein. Our current understanding of each of the four components and their interaction in the context of cargo selection are considered in turn.
Related Papers
- → Regulation of selective autophagy: the p62/SQSTM1 paradigm(2017)728 cited
- → Dual roles of Atg8−PE deconjugation by Atg4 in autophagy(2012)238 cited
- Death and survival of neuronal and astrocytic cells in ischemic brain injury： a role of autophagy(2011)
- → Is Selective Autophagy Distinct from Starvation-Induced Autophagy?(2016)
- Autophagy in cancer biology and therapy(2014)