ER-mitochondria contacts as sites of mitophagosome formation

Citations Over TimeTop 15% of 2014 papers

Abstract

Mitophagy is a degradative process that adapts the quantity and quality of mitochondria to the cellular needs. Mitochondria destined for degradation are marked by specific receptors that recruit the core autophagic machinery to the organellar surface. The organelle is then enclosed by a phagophore (PG) which fuses with the lysosome or vacuole where the mitochondrion is degraded. In spite of significant progress in recent years, several parts of the molecular machinery of mitophagy remain unknown. We used yeast as a model organism to screen for novel components and identified the mitochondria-ER tether ERMES (ER-mitochondria encounter structure) as a major player contributing to mitophagy and formation of mitophagosomes. Tethering of mitochondria to the ER appears to be important to supply the growing PG with lipids synthesized in the ER.

Related Papers

• → Lysosome biology in autophagy(2020)764 cited
• → Autophagic lysosome reformation(2012)113 cited
• → The Pathological Mechanism of Neuronal Autophagy-Lysosome Dysfunction After Ischemic Stroke(2023)14 cited
• → Characteristics of weak base-induced vacuoles formed around individual acidic organelles(2011)5 cited
• → Autophagy and Vacuole Formation(2017)2 cited