Tumor-derived exosomes
Citations Over TimeTop 10% of 2014 papers
Abstract
Intercellular communication is a key process in the development and progression of cancer. The dynamic and reciprocal interplays between the tumor and its microenvironment orchestrate events critical to the establishment of primary and metastatic niches and maintenance of a permissive environment at the tumor-stroma interface. Atay and colleagues found that gastrointestinal stromal tumor cells secrete vesicles known as exosomes. These exosomes contain oncogenic KIT and their transfer and uptake by surrounding smooth muscle cells lead to enhanced AKT and MAPK signaling and phenotypic modulation of several cellular processes, including morphological changes, expression of tumor-associated markers, secretion of matrix metalloproteinases, and enhanced tumor cell invasion. This provocative study emphasizes that exosome-mediated signaling within the tumor microenvironment acts as a positive feedback loop that contributes to invasiveness and that interfering with this message delivery system may represent promising therapeutic approaches, not only for GIST, but for other types of cancer.
Related Papers
- → Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance(2019)1,509 cited
- → Prions and exosomes: From PrPc trafficking to PrPsc propagation(2005)90 cited
- → Tumor–Stromal Cell Communication: Small Vesicles Signal Big Changes(2016)33 cited
- → Recent Advances in Experimental Models of Breast Cancer Exosome Secretion, Characterization and Function(2020)15 cited
- → Abstract 5095: Hic-5 modulation of the stromal matrix is required for mammary tumor progression(2016)