RESEARCH PAPER<br>Sensitivity analysis of mathematical modelsof signaling pathways
Citations Over TimeTop 22% of 2014 papers
Abstract
Modeling the dynamic behavior of signal transduction pathways is an important topic in systems biology. Mathematical<br /> models complement experimental technologies used to identify the molecular components and interactions<br /> in a system of interest. In this paper, we illustrate different types of mathematical approaches that are<br /> used to model signaling network behavior. Here, we review the basic methods of sensitivity analysis and apply<br /> them to the model of the system of membrane receptors. Four such receptors are considered: growth factor epidermal,<br /> low density lipoprotein, transferrin and vitellogenin receptor. We argue that application of sensitivity analysis<br /> methods provides an insight into how a signaling system controls the cell behavior.
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