MRI-directed cognitive fusion-guided biopsy of the anterior prostate tumors

Citations Over TimeTop 10% of 2017 papers

Abstract

PURPOSE: We aimed to evaluate the efficacy of magnetic resonance imaging (MRI)-directed cognitive fusion transrectal ultrasonography (TRUS)-guided anterior prostate biopsy for diagnosis of anterior prostate tumors and to illustrate this technique. METHODS: A total of 39 patients with previous negative TRUS biopsy, but high clinical suspicion of occult prostate cancer, prospectively underwent prostate MRI including diffusion-weighted imaging (DWI). Patients with a suspicious anterior lesion on MRI underwent targeted anterior gland TRUS-guided biopsy with cognitive fusion technique using sagittal probe orientation. PIRADS version 1 scores (T2, DWI, and overall), lesion size, prostate-specific antigen (PSA), PSA density, and prostate gland volume were compared between positive and negative biopsy groups and between clinically significant cancer and remaining cases. Logistic regression analysis of imaging parameters and prostate cancer diagnosis was performed. RESULTS: Anterior gland prostate adenocarcinoma was diagnosed in 18 patients (46.2%) on targeted anterior gland TRUS-guided biopsy. Clinically significant prostate cancer was diagnosed in 13 patients (33.3%). MRI lesion size, T2, DWI, and overall PIRADS scores were significantly higher in patients with positive targeted biopsies and those with clinically significant cancer (P < 0.05). Biopsies were positive in 90%, 33%, and 29% of patients with overall PIRADS scores of 5, 4, and 3 respectively. Overall PIRADS score was an independent predictor of all prostate cancer diagnosis and of clinically significant prostate cancer diagnosis. CONCLUSION: Targeted anterior gland TRUS-guided biopsy with MRI-directed cognitive fusion enables accurate sampling and may improve tumor detection yield of anterior prostate cancer.

Related Papers

• → The Effect of Different Types of Prostate Biopsy Techniques on Post-Biopsy Infectious Complications(2022)27 cited
• → A Cancer-Indicative microRNA Pattern in Normal Prostate Tissue(2013)17 cited
• → Prostate cancers detected on repeat prostate biopsies show spatial distributions that differ from those detected on the initial biopsies(2014)7 cited
• → CSR1 Suppresses Tumor Growth and Metastasis of Prostate Cancer(2006)1 cited
• THE EXPRESSIONS OF MITOSIS REGULATIVE FACTOR STK-15 IN PROSTATE CANCER(2009)