Diagnosis of Malignant Melanoma by 5-S-Cysteinyldopa.

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Abstract

Diagnosis of Malignant Melanoma by 5-S-CysteinyldopaWe have developed a new diagnostic method for malignant melanoma by histo-chemical demonstration and chemical assay of 5-S-cysteinyldopa (5-S-CD) which is a main intermediate product of melanin metabolism. The diagnostic process for the primary lesion of malignant melanoma being performed at our department is as follows:1. The stage is estimated by measuring urinary 5-S-CD value. 2. As a preoperative diagnostic method if it is an ulcerative lesion, touch-fluorescence method from the surface of the lesion and 5-S-CD value in the exudate in the gauze are made and if it is a non-ulcerative lesion, fine needle aspiration fluorescence method is used. 3. As a quick diagnostic method during operation touch-fluorescence method from the section of the lesion and measurement of 5-S-CD value in the lesion are made. 4. Decision of the morbid type is made from the fluorescence findings from the formalin-fixed and paraffin-embedded unstained specimen. 5. As a tumor marker, measurements are made of urinary and hematic 5-S-CD value with time.

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