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Correlation between the pharmacological efficacy of cyclosporine and tacrolimus as evaluated by the lymphocyte immunosuppressant sensitivity test (LIST) and the MTT assay procedure in patients before and after renal transplantation
International Journal of Clinical Pharmacology and Therapeutics2011Vol. 49(02), pp. 145–152
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Kentaro Sugiyama, Koji Isogai, Akira Toyama, Hiroshi Satoh, Kiyoshi Saito, Yuki Nakagawa, Masayuki Tasaki, Kazuhiro Takahashi, Toshihiko Hirano
Abstract
Both cyclosporine and tacrolimus exhibit pharmacological efficacy by the inhibition of calcineurin. However, the correlation between cyclosporine and tacrolimus pharmacological efficacies may be altered, due to immunosuppressive therapy or clinical events at 3 months after renal transplantation.
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