Proton Pump Inhibitor Clinical Trials: Focus On Lansoprazole In The Treatment Of Gastroesophageal Reflux Disease And Frequent Heartburn
Abstract
Purpose: Heartburn is a common symptom among adults, and can be troublesome when experienced more than two times a week. Heartburn and regurgitation are characteristic symptoms of gastroesophageal reflux disease, and may be experienced alone or in combination with other symptoms of reflux. The nurse practitioner should be aware of recent developments in the management of frequent heartburn that may be relevant to patients with this condition. Therefore the present review discusses the current treatment options for frequent heartburn with a focus on lansoprazole 15 mg, a recently approved over-the-counter proton pump inhibitor for frequent heartburn. Methods: The role of lansoprazole in the treatment of gastroesophageal reflux disease and heartburn was assessed using an online database search using PubMed, supplemented by the author’s knowledge of the management of the disease.Conclusions: The management of frequent heartburn is an important issue for nurse practitioners. Available pharmacologic treatments include antacids, histamine2-receptor antagonists, and proton pump inhibitors. The latter are the agents of choice for treatment as they have been available by prescription for many years. These agents have proven efficacy and excellent safety and tolerability profiles. Lansoprazole has recently been approved for over-the-counter sale for the short-term (14 days) treatment of frequent heartburn.Implications for practice: Nurse practitioners should be aware of the evidence to support the change in status of lansoprazole from prescription to over-the-counter, in order to appropriately advise their patients.
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