Challenges in Diagnosing Narcolepsy without Cataplexy: A Consensus Statement
SLEEP2014Vol. 37(6), pp. 1035–1042
Citations Over TimeTop 10% of 2014 papers
Christian R. Baumann, Emmanuel Mignot, Gert Jan Lammers, Sebastiaan Overeem, Isabelle Arnulf, David B. Rye, Yves Dauvilliers, Makoto Honda, Judith Owens, Giuseppe Plazzi, Thomas E. Scammell
Abstract
To aid in the identification of narcolepsy without cataplexy, we review key indicators of narcolepsy and present a diagnostic algorithm. A detailed clinical history is mainly helpful to rule out other possible causes of chronic sleepiness. The multiple sleep latency test remains the most important measure, and prior sleep deprivation, shift work, or circadian disorders should be excluded by actigraphy or sleep logs. A short REM sleep latency (≤ 15 minutes) on polysomnography can aid in the diagnosis of narcolepsy without cataplexy, although sensitivity is low. Finally, measurement of hypocretin levels can helpful, as levels are low to intermediate in 10% to 30% of narcolepsy without cataplexy patients.
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