Mechanisms of Humoral Hypercalcemia of Malignancy in Leukemia/Lymphoma
InTech eBooks2011
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Abstract
T-Cell Leukemia 182 cancer-derived hypercalcemic factors stimulate osteoclastic bone resorption indirectly by inducing osteoclast-stimulating factors from osteoblasts or bone stromal cells. Under normal physiological conditions, increased serum calcium concentration can be compensated for by decreasing the intestinal calcium absorption, increasing renal calcium excretion, decreasing PTH secretion from the parathyroid glands, and decreasing bone resorption. However, secretion of the cancer-related factor, parathyroid hormone-related protein (PTHrP), also increases renal calcium reabsorption in the kidney through the activation of parathyroid hormone receptor 1 (PTH1R), which facilitates the development of HHM. www.intechopen.com
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