Kojic Acid Derivatives
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Abstract
Medicinal Chemistry and Drug Design 2 browning in fruits and vegetables.In the food industry, tyrosinase is important in controlling the quality and economics of fruits and vegetables.Hence, tyrosinase inhibitors from natural sources have great potential in the food industry, as they are considered to be safe and largely free from adverse effects.Also in insects, tyrosinase is involved in melanogenesis wound healing, parasite encapsulation and sclerotisation (Seo, 2003).Therefore, tyrosinase inhibitors used as insecticides and insect control agents.Moreover, the tyrosinase is responsible from melanization in animals and is the key enzyme for the regulation of melanogenesis in mammals.Melanogenesis is the process by which melanin is produced and subsequently distributed by melanocytes within the skin and hair follicles.This process results in the synthesis of melanin pigments, which play a protective role against skin photocarcinogenesis (Khan, 2007;Kim, 2005).
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