Genomic Integrity of Mouse Embryonic Stem Cells

Citations Over TimeTop 14% of 2012 papers

Abstract

Embryonic stem (ES) cells are isolated from the inner cell mass (ICM) of a blastocyst stage embryo, which consists of a layer of trophoblast cells lining the ICM and blastocoel or blastocyst cavity. The ICM and trophoblast cells give rise to the embryo proper and extraembryonic tissue, respectively. Thirthy years ago the in vitro culture of mouse ES (mES) cells was first described ES cells are characterized by the unique properties of unlimited self-renewal without senescence and pluripotency. The latter infers that ES cells give rise to all cell types of the body. These specific properties led to the great scientific interest in ES cell either for their potential medical applications or as models to address more fundamental questions in development.

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