Neurulation and the Possible Etiologies of Neural Tube Defect
IntechOpen eBooks2023
Citations Over TimeTop 14% of 2023 papers
Abstract
Neural tube defects (NTDs) are variety of defects which result from abnormal closure of the neural tube during embryogenesis. Various factors are implicated in the genesis of neural tube defects, with contributions from both genetic and environmental factors. The clear understanding of the causes which leads to NTDs is lacking, but several non-genetic risk factors have been identified which can be prevented by maternal folic acid supplementation. Multiple genetic causes and several critical biochemical reactions have been identified whose regulation is essential for the closure of neural tube. Preventive therapies can be developed by identifying potential risk factors in the genesis of NTDs.
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