MiR-138-5p Targets MACF1 to Aggravate Aging-related Bone Loss

Citations Over TimeTop 10% of 2022 papers

Abstract

Senile osteoporosis is one of the major health problems in an aging society. Decreased bone formation due to osteoblast dysfunction may be one of the causes of aging-related bone loss. With increasing evidence suggesting that multiple microRNAs (miRNAs) play important roles in osteoblast function, the relationship between miRNAs and senile osteoporosis has become a popular research topic. Previously, we confirmed that mechanoresponsive miR-138-5p negatively regulated bone anabolic action. In this study, the miR-138-5p level was found to be negatively correlated with BMD and osteogenic markers in bone specimens of senile osteoporotic patients by bioinformatic analysis and experimental verification. Furthermore, high miR-138-5p levels aggravated the decrease of aged osteoblast differentiation in vitro and led to worse bone loss in aged osteoblastic miR-138-5p transgenic mice in vivo. We also previously identified that the target of miR-138-5p, microtubule actin cross-linking factor 1 (MACF1), could attenuate senile osteoporosis. Here, miR-138-5p was demonstrated to regulate aged osteoblast differentiation by targeting MACF1. Finally, the therapeutic inhibition of miR-138-5p counteracted the decrease in bone formation and aging-related bone loss in aged mice. Overall, our results highlight the crucial roles and the molecular mechanism of miR-138-5p in aging-related bone loss and may provide a powerful therapeutic target for ameliorating senile osteoporosis.

Related Papers

• → Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells(2020)268 cited
• The drug treatment of Osteoporosis(2014)
• A Study of the Male Senile Osteoporosis, Its incidence, Diagnosis and Treatment(1999)
• Surgical Treatment for Senile Osteoporosis Fractures(2013)
• Biological characteristics of bone in SAMP6 as a murine model for senile osteoporosis(2006)