PD-L1 Expression in Clear Cell Renal Cell Carcinoma: An Analysis of Nephrectomy and Sites of Metastases
Journal of Cancer2014Vol. 5(3), pp. 166–172
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Lucia B. Jilaveanu, Brian Shuch, Christopher R. Zito, Francesco Parisi, Meaghan L. Barr, Yuval Kluger, Lieping Chen, Harriet M. Kluger
Abstract
The weak correlation between PD-L1 expression in primary and metastatic sites for a given patient suggests that expression in nephrectomy specimens cannot be used to select metastatic RCC patients for PD-L1 and PD-1 inhibitors. The intra-tumor heterogeneity seen in both primary and metastatic specimens indicates that a single core biopsy might not be sufficient to determine PD-L1 expression.
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