F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects

Citations Over TimeTop 10% of 2020 papers

Abstract

E3 ubiquitin ligases play a critical role in cellular mechanisms and cancer progression. F-box protein is the core component of the SKP1-cullin 1-F-box (SCF)-type E3 ubiquitin ligase and directly binds to substrates by various specific domains. According to the specific domains, F-box proteins are further classified into three sub-families: 1) F-box with leucine rich amino acid repeats (FBXL); 2) F-box with WD 40 amino acid repeats (FBXW); 3) F-box only with uncharacterized domains (FBXO). Here, we summarize the substrates of F-box proteins, discuss the important molecular mechanism and emerging role of F-box proteins especially from the perspective of cancer development and progression. These findings will shed new light on malignant tumor progression mechanisms, and suggest the potential role of F-box proteins as cancer biomarkers and therapeutic targets for future cancer treatment.

Related Papers

• → The Biological Function and Roles in Phytohormone Signaling of the F-Box Protein in Plants(2021)30 cited
• → SKP1-like-related genes interact with various F-box proteins and may form SCF complexes with Cullin–F-box proteins in wheat(2012)36 cited
• → Combinatorial diversity of fission yeast SCF ubiquitin ligases by homo- and heterooligomeric assemblies of the F-box proteins Pop1p and Pop2p(2002)42 cited
• → AtSKIP18 and AtSKIP31, F-box subunits of the SCF E3 ubiquitin ligase complex, mediate the degradation of 14-3-3 proteins in Arabidopsis(2017)16 cited
• → Identification of Elongin C and Skp1 Sequences That Determine Cullin Selection(2004)11 cited