Photosensitizer Loaded Nano-Graphene for Multimodality Imaging Guided Tumor Photodynamic Therapy
Citations Over TimeTop 1% of 2014 papers
Abstract
Graphene, a 2-dimensional carbon nanomaterial, has attracted wide attention in biomedical applications, owing to its intrinsic physical and chemical properties. In this work, a photosensitizer molecule, 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-alpha (HPPH or Photochlor®), is loaded onto polyethylene glycol (PEG)-functionalized graphene oxide (GO) via supramolecular π-π stacking. The obtained GO-PEG-HPPH complex shows high HPPH loading efficiency. The in vivo distribution and delivery were tracked by fluorescence imaging as well as positron emission tomography (PET) after radiolabeling of HPPH with (64)Cu. Compared with free HPPH, GO-PEG-HPPH offers dramatically improved photodynamic cancer cell killing efficacy due to the increased tumor delivery of HPPH. Our study identifies a role for graphene as a carrier of PDT agents to improve PDT efficacy and increase long-term survival following treatment.
Related Papers
- → Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy(2015)923 cited
- → Fluorous photosensitizers enhance photodynamic therapy with perfluorocarbon nanoemulsions(2017)75 cited
- → Fluorous photosensitizers enhance photodynamic therapy with perfluorocarbon nanoemulsions(2017)4 cited
- → Research advances in action mechanisms of photodynamic therapy and photosensitizer(2016)
- → Fluorous photosensitizers enhance photodynamic therapy with perfluorocarbon nanoemulsions(2017)