Expression Analysis of MiR-21, MiR-205, and MiR-342 in Breast Cancer in Iran

Citations Over TimeTop 10% of 2012 papers

Abstract

MicroRNAs (miRNAs) are short non-coding RNA molecules characterized by their regulatory roles in cancer and gene expression. We analyzed the expression of miR-21, miR-205, and miR-342 in 59 patients with breast cancer. Samples were divided into three different groups according to their immunohistochemistry (IHC) classification: ER-positive and/or PR-positive group (ER+ and/or PR+; group I); HER2-positive group (HER2+; group II); and ER/PR/HER2- negative (ER-/PR-/HER2-; group III) as the triple negative group. The expression levels of the 3 miRNAs were analyzed in the tumor samples and the compared with the normal neighboring dissected tumor (NNDT) samples in all three groups. The expression of miR-21 was similar in all three groups. In patients positive for P53 by IHC, positive for axillary lymph node metastasis and higher tumor stages, it appeared to have significantly elevated. However, significant increase was not found among the 18 fibroadenoma samples. Both miR-205 and miR-342 expressions were significantly down regulated in group III. We conclude that miR-21 does not discriminate between different breast cancer groups. In contrast, miR-205 and miR-342 may be used as potential biomarkers for diagnosis of triple negative breast cancer.

Related Papers

• → MicroRNA-21 versus microRNA-34: Lung cancer promoting and inhibitory microRNAs analysed in silico and in vitro and their clinical impact(2017)22 cited
• → Therapeutic modulation of microRNAs(2013)2 cited
• → Circulating microRNAs as Novel Biomarkers for Exercise Stress(2012)
• → Προσδιορισμός κυκλοφορούντων oncomiRs και angiomiRs στο αίμα ασθενών με καρκίνο και διερεύνηση της διαγνωστικής, προγνωστικής και προβλεπτικής τους ικανότητας(2016)
• Expression profiles of miRNAs in human pancreatic cancer cell lines(2009)