Composite Outcomes in Cardiovascular Research: A Survey of Randomized Trials
Annals of Internal Medicine2008Vol. 149(9), pp. 612–617
Citations Over TimeTop 1% of 2008 papers
Abstract
Composite outcomes in cardiovascular trials are frequent and commonly comprise 3 to 4 individual end points that vary in clinical significance. Discrepancies between the total number of individual events in a trial and those reported for composite outcomes are common. Individual outcomes do not contribute equally to composite measures, so the overall estimate of effect for a composite measure cannot be assumed to apply equally to each of its individual outcomes.
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