A new aggressive xenograft model of human colon cancer using cancer-associated fibroblasts
PeerJ2020Vol. 8, pp. e9045–e9045
Citations Over Time
Ester Fernando-Macías, María Teresa Fernández‐García, Eva García-Pérez, Belén Porrero Guerrero, Camilo López-Arévalo, Raquel Rodríguez Uría, Sandra Sanz Navarro, Fernando Vázquez, María Muñíz-Salgueiro, Laura Suárez–Fernández, José A. Galván, Clara Barneo-Caragol, Marcos García-Ocaña, Juan R. de los Toyos, Luis Barneo
Abstract
Our experiments demonstrate that cultured CAFs have a higher growth than NF and that when human CAFs are associated to human tumor cells, larger tumors with liver and lung metastases are generated than if only colon cancer cells with/without NF are transplanted. This emphasizes the importance of the tumor stroma, and especially the CAFs, in the development of cancer.
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