James R. Burke
Bristol-Myers Squibb (United States)(US)
Publications by Year
Research Areas
Cytokine Signaling Pathways and Interactions, NF-κB Signaling Pathways, Chronic Lymphocytic Leukemia Research, Protein Kinase Regulation and GTPase Signaling, Immune Response and Inflammation
Most-Cited Works
- → BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice(2003)538 cited
- → Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165(2019)356 cited
- → Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain(2019)272 cited
- → IKK mediates ischemia-induced neuronal death(2005)260 cited
- → Duration and Intensity of NF-κB Activity Determine the Severity of Endotoxin-Induced Acute Lung Injury(2006)232 cited
- → A highly selective inhibitor of IκB kinase, BMS‐345541, blocks both joint inflammation and destruction in collagen‐induced arthritis in mice(2003)217 cited