Richard Goldsmith
Publications by Year
Research Areas
PI3K/AKT/mTOR signaling in cancer, Chemical Synthesis and Analysis, Protein Kinase Regulation and GTPase Signaling, Carbohydrate Chemistry and Synthesis, Click Chemistry and Applications
Most-Cited Works
- → Sequence-specific polypeptoids: A diverse family of heteropolymers with stable secondary structure(1998)473 cited
- → GDC-0449—A potent inhibitor of the hedgehog pathway(2009)385 cited
- → Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance(2010)363 cited
- → NMR determination of the major solution conformation of a peptoid pentamer with chiral side chains(1998)299 cited
- → Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer(2011)215 cited
- → [25] Synthesis of N-substituted glycine peptoid libraries(1996)198 cited
- → Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1H-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity(2013)175 cited
- → Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer(2010)131 cited
- → Rational Design of Phosphoinositide 3-Kinase α Inhibitors That Exhibit Selectivity over the Phosphoinositide 3-Kinase β Isoform(2011)70 cited
- → The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3-Kinase α(2012)52 cited