Theresa J. Roethke
GlaxoSmithKline (United States)(US)
Publications by Year
Research Areas
Ion Channels and Receptors, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, Respiratory and Cough-Related Research, Protein Kinase Regulation and GTPase Signaling
Most-Cited Works
- → An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure(2012)328 cited
- → Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4(2017)95 cited
- → Structure Activity Relationships of 5-, 6-, and 7-Methyl-Substituted Azepan-3-one Cathepsin K Inhibitors(2006)70 cited
- → Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase(2013)64 cited
- → Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4)(2019)52 cited
- → Antagonists of the Calcium Receptor I. Amino Alcohol-Based Parathyroid Hormone Secretagogues(2009)42 cited
- → Preclinical Pharmacokinetics and Interspecies Scaling of a Novel Vitronectin Receptor Antagonist(1999)39 cited
- → Comparison of N,N′-diarylsquaramides and N,N′-diarylureas as antagonists of the CXCR2 chemokine receptor(2006)37 cited
- → Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model(2018)34 cited
- → Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema(2013)30 cited