W.W. Prosise
Merck & Co., Inc., Rahway, NJ, USA (United States)(US)
Publications by Year
Research Areas
Monoclonal and Polyclonal Antibodies Research, Hepatitis C virus research, Computational Drug Discovery Methods, Hepatitis B Virus Studies, HIV/AIDS drug development and treatment
Most-Cited Works
- → Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease–helicase(1999)378 cited
- → Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis(2018)262 cited
- → Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab(2015)248 cited
- → Construction, expression, and characterization of a novel fully activated recombinant single‐chain hepatitis C virus protease(1998)116 cited
- → Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization(2007)107 cited
- → Crystal Structure of the Catalytic Domain of Human ADAM33(2003)91 cited
- → Pembrolizumab microgravity crystallization experimentation(2019)56 cited
- → Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core(2010)35 cited
- → Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors(2016)17 cited
- → Synthetic mimics of juxtaposed amino- and carboxyl-terminal peptide domains of human gamma interferon block ligand binding to human gamma interferon receptor.(1994)15 cited