Eddine Saiah
Publications by Year
Research Areas
Hormonal Regulation and Hypertension, Protein Kinase Regulation and GTPase Signaling, Computational Drug Discovery Methods, Melanoma and MAPK Pathways, Crystallization and Solubility Studies
Most-Cited Works
- → Approaches to discover non-ATP site kinase inhibitors(2012)173 cited
- → Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S )-2,2-Difluorocyclopropyl)((1 R ,5 S )-3-(2-((1-methyl-1 H -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)(2018)170 cited
- → Discovery of Clinical Candidate 1-{[(2 S ,3 S ,4 S )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design(2017)139 cited
- → A small molecule inhibitor of Rheb selectively targets mTORC1 signaling(2018)96 cited
- → SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models(2016)86 cited
- → Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation(2019)83 cited
- → Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases(2020)73 cited
- → Discovery of NV-5138, the first selective Brain mTORC1 activator(2019)67 cited
- → Efficacious 11β-Hydroxysteroid Dehydrogenase Type I Inhibitors in the Diet-Induced Obesity Mouse Model(2009)63 cited
- → Ketene Dithioacetals in the Aza-Diels−Alder Reaction with N-Arylimines: A Versatile Approach to Tetrahydroquinolines, 2,3-Dihydro-4-quinolones, and 4-Quinolones(2002)59 cited