Emanuele Perola
Blueprint Medicines (United States)(US)
Publications by Year
Research Areas
Computational Drug Discovery Methods, Cancer therapeutics and mechanisms, Protein Structure and Dynamics, Cholinesterase and Neurodegenerative Diseases, Influenza Virus Research Studies
Most-Cited Works
- → A detailed comparison of current docking and scoring methods on systems of pharmaceutical relevance(2004)448 cited
- → Conformational Analysis of Drug-Like Molecules Bound to Proteins: An Extensive Study of Ligand Reorganization upon Binding(2004)444 cited
- → Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment(2015)268 cited
- → Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships(2008)222 cited
- → Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2(2014)210 cited
- → An Analysis of the Binding Efficiencies of Drugs and Their Leads in Successful Drug Discovery Programs(2010)191 cited
- → Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit(2014)186 cited
- → Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer(2022)154 cited
- → Three-dimensional structure of a complex of galanthamine (Nivalin�) with acetylcholinesterase fromTorpedo californica: Implications for the design of new anti-Alzheimer drugs(2000)146 cited
- → Successful Virtual Screening of a Chemical Database for Farnesyltransferase Inhibitor Leads(2000)130 cited