John P. Wolak
Boehringer Ingelheim (United States)(US)
Publications by Year
Research Areas
Quinazolinone synthesis and applications, Protein Kinase Regulation and GTPase Signaling, Cell Adhesion Molecules Research, CAR-T cell therapy research, Cytokine Signaling Pathways and Interactions
Most-Cited Works
- → Three Mechanistically Distinct Kinase Assays Compared: Measurement of Intrinsic ATPase Activity Identified the Most Comprehensive Set of ITK Inhibitors(2006)132 cited
- → Hit to Lead Account of the Discovery of a New Class of Inhibitors of Pim Kinases and Crystallographic Studies Revealing an Unusual Kinase Binding Mode(2009)69 cited
- → Discovery of potent and selective PKC-θ inhibitors(2006)69 cited
- → Hit-to-lead studies on benzimidazole inhibitors of ITK: Discovery of a novel class of kinase inhibitors(2007)65 cited
- → Optimization of 2-Phenylaminoimidazo[4,5-h]isoquinolin-9-ones: Orally Active Inhibitors of lck Kinase(2003)45 cited
- → Discovery of potent inhibitors of interleukin-2 inducible T-cell kinase (ITK) through structure-based drug design(2008)33 cited
- → Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)(2008)32 cited
- → 5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk)(2008)24 cited
- → 2-Aminobenzimidazoles as potent ITK antagonists: de novo design of a pyrrole system targeting additional hydrogen bonding interaction(2008)19 cited
- → A High-Throughput Scintillation Proximity Assay for Sphingosine-1-Phosphate Lyase(2014)12 cited