R. E. PIKE
Publications by Year
Research Areas
Asymmetric Synthesis and Catalysis, Synthetic Organic Chemistry Methods, Synthesis and biological activity, Chemical Synthesis and Analysis, Cyclopropane Reaction Mechanisms
Most-Cited Works
- → Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor(2010)97 cited
- → Highly stereoselective access to novel 2,2,4-substituted tetrahydrofurans by halocyclization: Practical chemoenzymatic synthesis of Sch 51048, a broad-spectrum orally active antifungal agent(1995)41 cited
- → Total synthesis and absolute stereochemistry of the antifungal dipeptide Sch 37137 and its 2S,3S - isomer(1993)34 cited
- → Enantioselective synthesis of the optical isomers of broad-spectrum orally active antifungal azoles, Sch 42538 and Sch 45012(1994)28 cited
- → Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048)(2007)21 cited
- → Ring contraction reactions of 2-O-methanesulfonates of α-hydroxy-γ-lactones in aqueous medium to oxetane-2-carboxylic acids: A convenient synthesis of 3′-O-methyloxetanocin and a formal synthesis of oxetanocin(1992)20 cited
- → A novel synthesis of -1-[[6-chloro-3-[(2-chloro-3-thienyl)methoxy]-2,3-dihydrobenzo[b]thien-2-yl]methyl]1h-imidazole(1988)20 cited
- → Toward Second Generation Hepatitis C Virus NS3 Serine Protease Inhibitors: Discovery of Novel P4 Modified Analogues with Improved Potency and Pharmacokinetic Profile(2009)19 cited
- → Aqueous Diels-Alder Reactions of Electron Deficient 2-Arylfurans: A Highly Stereoselective Route to 2,2,5-Trisubstituted Tetrahydrofurans towards a Novel Class of Orally Active Azole Antifungals(1993)18 cited
- → .beta.-Adrenergic blockade by 3-[3-(substituted amino)-2-hydroxypropoxy]-5-hydroxybenzyl alcohols(1975)15 cited