David Sperandio
Frontier Medicines (United States)
Publications by Year
Research Areas
Mast cells and histamine, Synthesis and Biological Evaluation, Synthesis and biological activity, Chemical Synthesis and Analysis, Synthesis and Properties of Aromatic Compounds
Most-Cited Works
- → Discovery of an Oral Respiratory Syncytial Virus (RSV) Fusion Inhibitor (GS-5806) and Clinical Proof of Concept in a Human RSV Challenge Study(2015)122 cited
- → Synthesis of 3,5-disubstituted-1,2,4-oxadiazoles using tetrabutylammonium fluoride as a mild and efficient catalyst(2001)121 cited
- → A New and Selective Catalyst for the [5 + 2] Cycloaddition of Vinylcyclopropanes and Alkynes(1998)117 cited
- → The Structure of the Extracellular Region of Human Hepsin Reveals a Serine Protease Domain and a Novel Scavenger Receptor Cysteine-Rich (SRCR) Domain(2003)85 cited
- → Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle(2018)76 cited
- → Design, synthesis, and anti-HIV activity of 4′-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors(2008)56 cited
- → Phenotypic screening with deep learning identifies HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopathy(2022)45 cited
- → Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β–dependent mechanisms(2016)43 cited
- → Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease(2002)40 cited
- → GS-5806 Inhibits Pre- to Postfusion Conformational Changes of the Respiratory Syncytial Virus Fusion Protein(2015)38 cited