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Wynne Aherne | doi.page

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Wynne Aherne

Institute of Cancer Research(GB)Cancer Research UK(GB)

Publications by Year

Research Areas

Heat shock proteins research, Endoplasmic Reticulum Stress and Disease, Enzyme Structure and Function, Cancer-related gene regulation, ATP Synthase and ATPases Research

Most-Cited Works

→ NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis(2008)476 cited
→ 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer(2007)442 cited
→ Structure-Activity Relationships in Purine-Based Inhibitor Binding to HSP90 Isoforms(2004)266 cited
→ Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response(2011)250 cited
→ High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity(2004)194 cited
→ A Phase I Study of the Heat Shock Protein 90 Inhibitor Alvespimycin (17-DMAG) Given Intravenously to Patients with Advanced Solid Tumors(2011)189 cited

→ Identification of Novel Small Molecule Inhibitors of Hypoxia-Inducible Factor-1 That Differentially Block Hypoxia-Inducible Factor-1 Activity and Hypoxia-Inducible Factor-1α Induction in Response to Hypoxic Stress and Growth Factors(2005)

146 cited

→ Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues(2007)142 cited

→ Gene and Protein Expression Profiling of Human Ovarian Cancer Cells Treated with the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin(2007)141 cited

→ A human capecitabine excretion balance and pharmacokinetic study after administration of a single oral dose of 14C-labelled drug(1999)120 cited