Jeffrey R. Simard
C4 Therapeutics (United States)(US)
Publications by Year
Research Areas
Lung Cancer Treatments and Mutations, Melanoma and MAPK Pathways, Computational Drug Discovery Methods, Cancer therapeutics and mechanisms, Cancer Mechanisms and Therapy
Most-Cited Works
- → Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer(2011)472 cited
- → Location of High and Low Affinity Fatty Acid Binding Sites on Human Serum Albumin Revealed by NMR Drug-competition Analysis(2006)338 cited
- → Locating high-affinity fatty acid-binding sites on albumin by x-ray crystallography and NMR spectroscopy(2005)267 cited
- → Chemogenomic Profiling Provides Insights into the Limited Activity of Irreversible EGFR Inhibitors in Tumor Cells Expressing the T790M EGFR Resistance Mutation(2010)218 cited
- → Development of a Fluorescent-Tagged Kinase Assay System for the Detection and Characterization of Allosteric Kinase Inhibitors(2009)148 cited
- → Hybrid Compound Design To Overcome the Gatekeeper T338M Mutation in cSrc(2009)141 cited
- → A new screening assay for allosteric inhibitors of cSrc(2009)125 cited
- → Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators(2016)123 cited
- → Role of Caveolin-1 and Cholesterol in Transmembrane Fatty Acid Movement(2006)105 cited
- → Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR(2008)90 cited