John McNulty
Takeda (United States)(US)
Publications by Year
Research Areas
Cancer therapeutics and mechanisms, DNA Repair Mechanisms, DNA and Nucleic Acid Chemistry, Antibiotics Pharmacokinetics and Efficacy, Antibiotic Resistance in Bacteria
Most-Cited Works
- → Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases(2015)100 cited
- → Replication Inhibition and Miscoding Properties of DNA Templates Containing a Site-Specific cis-Thymine Glycol or Urea Residue(1998)91 cited
- → Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pKa: Antibacterial Agents with an Improved Safety Profile(2012)89 cited
- → Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization(2014)56 cited
- → Apical sodium-dependent bile acid transporter inhibition with volixibat improves metabolic aspects and components of non-alcoholic steatohepatitis in Ldlr-/-.Leiden mice(2019)40 cited
- → Nonclinical Aspects of Biopharmaceutical Development: Discussion of Case Studies at a PhRMA-FDA Workshop(2008)28 cited
- → Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa(2014)24 cited
- → C8-Guanine Adduct-Induced Stabilization of a −1 Frame Shift Intermediate in a Nonrepetitive DNA Sequence(1999)13 cited
- → CCDC 1013311: Experimental Crystal Structure Determination(2015)
- In vitro and in vivo mutagenesis studies of site-specifically located DNA damages: Thymine glycol, urea, N-(guanin-8-yl)-1-aminopyrene, and ethenoadenine(1999)