David Buttar
AstraZeneca (United Kingdom)(GB)AstraZeneca (Brazil)(BR)
Publications by Year
Research Areas
Estrogen and related hormone effects, Computational Drug Discovery Methods, Machine Learning in Materials Science, Muon and positron interactions and applications, Cancer therapeutics and mechanisms
Most-Cited Works
- → Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases(2013)213 cited
- → AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1 -Mutant Breast Tumors in Preclinical Models(2016)174 cited
- → Machine learning meets mechanistic modelling for accurate prediction of experimental activation energies(2020)173 cited
- → Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist(2015)159 cited
- → Scaffold Hopping Using Clique Detection Applied to Reduced Graphs(2006)87 cited
- → A combined spectroscopic and crystallographic approach to probing drug–human serum albumin interactions