Jeffrey N. Higaki
Exelixis (United States)(US)
Publications by Year
Research Areas
HER2/EGFR in Cancer Research, Monoclonal and Polyclonal Antibodies Research, Peptidase Inhibition and Analysis, Amyloidosis: Diagnosis, Treatment, Outcomes, Alzheimer's disease research and treatments
Most-Cited Works
- → Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors(2000)301 cited
- → Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNS(1992)215 cited
- → Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism(1995)146 cited
- → Engineered metalloregulation in enzymes(1992)95 cited
- → Introduction of a cysteine protease active site into trypsin(1989)94 cited
- → Regulation of serine protease activity by an engineered metal switch(1990)90 cited
- → A Possible Role for Cathepsins D, E, and B in the Processing of β‐amyloid Precursor Protein in Alzheimer's Disease(1997)90 cited
- → Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin(2016)86 cited
- → Transthyretin amyloidosis: an under-recognized neuropathy and cardiomyopathy(2017)80 cited
- → Secretion of beta-amyloid precursor protein involves multiple cleavage sites.(1994)69 cited